3-(4-(4-fluorophenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)-pyridin-2(1H)-one

Base Information

Chemical Name:3-(4-(4-fluorophenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)-pyridin-2(1H)-one
CAS No.:1616763-45-1
Molecular Formula:C₂₁H₁₅FN₄O₂
Molecular Weight:374.374
Hs Code.:

Synonyms:3-(4-(4-fluorophenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)-pyridin-2(1H)-one

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Chemical Property of 3-(4-(4-fluorophenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)-pyridin-2(1H)-one

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Technology Process of 3-(4-(4-fluorophenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)-pyridin-2(1H)-one

There total 4 articles about 3-(4-(4-fluorophenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)-pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1616763-12-2
C₁₄H₁₀N₂O₃

: 456-14-4
4-fluorobenzamidine hydrochloride

: 1616763-45-1
3-(4-(4-fluorophenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)-pyridin-2(1H)-one

Guidance literature:: With potassium carbonate; In ethanol; at 130 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1021/jo5010668

Reference yield:

: 10366-35-5
2-chloronicotinamide

: 1616763-45-1
3-(4-(4-fluorophenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)-pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: dimethyl sulfoxide / 0.25 h / 150 °C / Microwave irradiation

3.1: potassium carbonate / ethanol / 0.17 h / 130 °C / Microwave irradiation

With sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; dimethyl sulfoxide; mineral oil;
DOI:10.1021/jo5010668

Reference yield:

: 1616763-16-6
sodium (2-chloronicotinoyl)(4-methoxybenzoyl)amide

: 1616763-45-1
3-(4-(4-fluorophenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)-pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 0.25 h / 150 °C / Microwave irradiation

2: potassium carbonate / ethanol / 0.17 h / 130 °C / Microwave irradiation

With potassium carbonate; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jo5010668