(Z)-N,N-diethyl-3-(2-hydroxy-3-(trimethylsilyl)phenyl)-2,3-diphenylacrylamide

Base Information

Chemical Name:(Z)-N,N-diethyl-3-(2-hydroxy-3-(trimethylsilyl)phenyl)-2,3-diphenylacrylamide
CAS No.:741695-84-1
Molecular Formula:C₂₈H₃₃NO₂Si
Molecular Weight:443.661
Hs Code.:

Synonyms:(Z)-N,N-diethyl-3-(2-hydroxy-3-(trimethylsilyl)phenyl)-2,3-diphenylacrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-N,N-diethyl-3-(2-hydroxy-3-(trimethylsilyl)phenyl)-2,3-diphenylacrylamide

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Technology Process of (Z)-N,N-diethyl-3-(2-hydroxy-3-(trimethylsilyl)phenyl)-2,3-diphenylacrylamide

There total 3 articles about (Z)-N,N-diethyl-3-(2-hydroxy-3-(trimethylsilyl)phenyl)-2,3-diphenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 741695-81-8
(E)-2-(1,2-diphenylvinyl)-6-(trimethylsilyl)phenyldiethylcarbamate

: 741695-84-1
(Z)-N,N-diethyl-3-(2-hydroxy-3-(trimethylsilyl)phenyl)-2,3-diphenylacrylamide

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at 20 ℃; for 2h;
DOI:10.1021/ol049740t

Reference yield:

: 65009-00-9
O-phenyl N,N-diethylcarbamate

: 741695-84-1
(Z)-N,N-diethyl-3-(2-hydroxy-3-(trimethylsilyl)phenyl)-2,3-diphenylacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: TMEDA; s-BuLi / tetrahydrofuran / 1 h / -78 - -30 °C

1.2: 77 percent / s-BuLi; I₂ / tetrahydrofuran / 3 h / -85 - 0 °C

2.1: 77 percent / Na₂CO₃ / Pd(PPh₃)4 / H₂O; 1,2-dimethoxy-ethane / 20 h / Heating

3.1: 92 percent / n-BuLi; iPr₂NH / hexane; tetrahydrofuran / 2 h / 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium carbonate; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; 2.1: Suzuki-Miyaura coupling;
DOI:10.1021/ol049740t

Reference yield:

: 741695-50-1
2-iodo-6-(trimethylsilyl)phenyl diethylcarbamate

: 741695-84-1
(Z)-N,N-diethyl-3-(2-hydroxy-3-(trimethylsilyl)phenyl)-2,3-diphenylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / Na₂CO₃ / Pd(PPh₃)4 / H₂O; 1,2-dimethoxy-ethane / 20 h / Heating

2: 92 percent / n-BuLi; iPr₂NH / hexane; tetrahydrofuran / 2 h / 20 °C

With n-butyllithium; sodium carbonate; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; 1: Suzuki-Miyaura coupling;
DOI:10.1021/ol049740t