7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one

Base Information

• Chemical Name: 7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one
• CAS No.: 1313365-33-1
• Molecular Formula: C₂₆H₂₅ClN₂O₅
• Molecular Weight: 480.948
• Mol file: 1313365-33-1.mol

Synonyms:7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one

Chemical Property of 7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one

There total 6 articles about 7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

[4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetyl chloride (1313364-77-0) + (4-chlorobenzylidene)(4-nitrophenyl)amine (5340-14-7) → 7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one (1313365-33-1)

Guidance literature:

[4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetyl chloride; (4-chlorobenzylidene)(4-nitrophenyl)amine; In dichloromethane; at 20 ℃; for 1h;

With methanesulfonic acid; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1016/j.bmcl.2015.06.058

Reference yield:

C14H20O4 → 7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one (1313365-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / ethanol / 2 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: dichloromethane / 1 h / 20 °C

3.2: 0.25 h / 0 °C

With oxalyl dichloride; water; N,N-dimethyl-formamide; lithium hydroxide; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2015.06.058

Reference yield:

2-(4-hydroxy-3-methoxyphenyl)acetic acid methyl ester (15964-80-4) → 7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one (1313365-33-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 20 °C

2.1: lithium hydroxide; water / ethanol / 2 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

4.1: dichloromethane / 1 h / 20 °C

4.2: 0.25 h / 0 °C

With oxalyl dichloride; di-tert-butyl-diazodicarboxylate; water; N,N-dimethyl-formamide; triphenylphosphine; lithium hydroxide; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2015.06.058

upstream raw materials:

2-(4-hydroxy-3-methoxyphenyl)acetic acid methyl ester

[4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid

[4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetyl chloride

(4-chlorobenzylidene)(4-nitrophenyl)amine

Downstream raw materials:

7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-{4-[(pyridin-4-ylmethyl)-amino]-phenyl}-1,4-dihydro-2H-isoquinolin-3-one

7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

{4-[({4-[7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-phenyl}-methyl-amino)-methyl]-trans-cyclohexyl}-carbamic acid tert-butyl ester

2-{4-[(trans-4-amino-cyclohexylmethyl)-methyl-amino]-phenyl}-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one