7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Base Information

Chemical Name:7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one
CAS No.:1313361-26-0
Molecular Formula:C₃₆H₄₆ClN₃O₃
Molecular Weight:604.233
Hs Code.:

Synonyms:7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

There total 3 articles about 7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313365-33-1
7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one

: 1313361-26-0
7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; iron / ethyl acetate; water / 1 h / 80 °C / Sealed flask

1.2: pH 7

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 1 h / 20 °C

2.3: 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 14 h / 20 °C

With sodium tris(acetoxy)borohydride; iron; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 1313365-34-2
2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: 1313361-26-0
7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 1 h / 20 °C

1.3: 1 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 14 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;

Reference yield:

: 1313365-39-7
{4-[({4-[7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-phenyl}-methyl-amino)-methyl]-trans-cyclohexyl}-carbamic acid tert-butyl ester

: 1313361-26-0
7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-{4-[(trans-4-ethylamino-cyclohexylmethyl)-methyl-amino]-phenyl}-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 14 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In dichloromethane;