((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester

Base Information

• Chemical Name: ((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester
• CAS No.: 1224445-82-2
• Molecular Formula: C₄₄H₄₃ClN₅O₆P
• Molecular Weight: 804.282

Synonyms:((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester

Chemical Property of ((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester

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Technology Process of ((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester

There total 1 articles about ((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester (1224445-77-5) + glycine ethyl ester hydrochloride (623-33-6) → ((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester (1224445-82-2)

Guidance literature:

With 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine; In pyridine; at 90 ℃; for 4h;

Reference yield:

((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester (1224445-82-2) → ((6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester (1224445-01-5)

Guidance literature:

With cyclohexa-1,3-diene; 20 % Pd(OH)2/C; In ethanol; at 120 ℃; for 0.5h;

upstream raw materials:

(5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester

glycine ethyl ester hydrochloride

Downstream raw materials:

((6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester

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