(5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester

Base Information

• Chemical Name: (5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester
• CAS No.: 1224445-77-5
• Molecular Formula: C₄₂H₄₅ClN₃O₄PSi₂
• Molecular Weight: 778.435

Synonyms:(5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester

Chemical Property of (5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester

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Technology Process of (5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester

There total 1 articles about (5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylsilyl bromide (2857-97-8) + (5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid diethyl ester (1224445-75-3) → (5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester (1224445-77-5)

Guidance literature:

With 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

(5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid bis(trimethylsilyl) ester (1224445-77-5) + glycine ethyl ester hydrochloride (623-33-6) → ((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester (1224445-82-2)

Guidance literature:

With 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine; In pyridine; at 90 ℃; for 4h;

upstream raw materials:

trimethylsilyl bromide

(5-(1-biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yloxy)-2-methylphenyl)phosphonic acid diethyl ester

Downstream raw materials:

((6-chloro-5-(1-methyl-1H-indol-5-yl)-1-biphenyl-4-ylmethyl-H-benzimidazol-2-yl)oxy)-4-methylphenyl-3-phosphonobis-2-aminoethanoic acid ethyl ester

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