3-(3,5-dibromo-4-hydroxyphenyl)-4-(3,5-dibromo-4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione

Base Information

Chemical Name:3-(3,5-dibromo-4-hydroxyphenyl)-4-(3,5-dibromo-4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione
CAS No.:283614-77-7
Molecular Formula:C₁₇H₈Br₄O₅
Molecular Weight:611.864
Hs Code.:

Synonyms:3-(3,5-dibromo-4-hydroxyphenyl)-4-(3,5-dibromo-4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione

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Chemical Property of 3-(3,5-dibromo-4-hydroxyphenyl)-4-(3,5-dibromo-4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione

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Technology Process of 3-(3,5-dibromo-4-hydroxyphenyl)-4-(3,5-dibromo-4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione

There total 12 articles about 3-(3,5-dibromo-4-hydroxyphenyl)-4-(3,5-dibromo-4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 283614-76-6
3-(3,5-dibromo-4-methoxy-phenyl)-4-(4-hydroxy-phenyl)-firan-2,5-dione

: 283614-77-7
3-(3,5-dibromo-4-hydroxyphenyl)-4-(3,5-dibromo-4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione

Guidance literature:: With bromine; In acetic acid; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(00)00168-X

Reference yield: 84.0%

: 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione

: 283614-77-7
3-(3,5-dibromo-4-hydroxyphenyl)-4-(3,5-dibromo-4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione

Guidance literature:: With tribromo-isocyanuric acid; trifluoroacetic acid; at 0 - 60 ℃; for 9h;
DOI:10.1002/ejoc.201301108

Reference yield:

: 23786-14-3
4-methoxy-phenyl acetic acid methyl ester

: 283614-77-7
3-(3,5-dibromo-4-hydroxyphenyl)-4-(3,5-dibromo-4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / Br₂; FeBr₂ / CHCl₃ / 96 h / 20 °C

2: 100 percent / NaOMe / methanol / 5 h / Heating

3: 84 percent / iPr₂NEt / CH₂Cl₂ / 0 - 20 °C

4: 81 percent / Ph₃P / tris(dibenzylideneacetone)dipalladium / dimethylformamide / 1 h / 70 - 75 °C

5: 92 percent / Me₃CiCl; NaI / acetonitrile / -20 - 20 °C

6: 77 percent / NaOMe / H₂O; methanol / 2 h / Heating

7: 89 percent / Br₂ / acetic acid / 1 h / 20 °C

With tertiary butyl chloride; bromine; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium iodide; iron(II) bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; 1: Bromination / 2: Condensation / 3: Substitution / 4: coupling / 5: Substitution / 6: Hydrolysis / 7: Bromination;
DOI:10.1016/S0040-4020(00)00168-X