1-(2,4-difluoro-phenyl)-3-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-thiourea

Base Information

• Chemical Name: 1-(2,4-difluoro-phenyl)-3-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-thiourea
• CAS No.: 380304-56-3
• Molecular Formula: C₁₁H₁₄F₂N₂O₃S
• Molecular Weight: 292.307
• Mol file: 380304-56-3.mol

Synonyms:1-(2,4-difluoro-phenyl)-3-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-thiourea

Chemical Property of 1-(2,4-difluoro-phenyl)-3-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,4-difluoro-phenyl)-3-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-thiourea

There total 3 articles about 1-(2,4-difluoro-phenyl)-3-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2,4-difluorophenyl isothiocyanate (141106-52-7) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → 1-(2,4-difluoro-phenyl)-3-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-thiourea (380304-56-3)

Guidance literature:

In ethyl acetate; for 12h; Heating;

DOI:10.1021/jf010632k

Reference yield:

2,4-difluorophenylamine (367-25-9,76563-56-9) → 1-(2,4-difluoro-phenyl)-3-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-thiourea (380304-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH / 24 h / 40 - 45 °C

2: 60.88 g / ethyl chloroformate / H₂O / 0.67 h / 35 - 40 °C

3: 58 percent / ethyl acetate / 12 h / Heating

With sodium hydroxide; chloroformic acid ethyl ester; In water; ethyl acetate;

DOI:10.1021/jf010632k

Reference yield:

C7H4F2NS2(1-)*Na(1+) → 1-(2,4-difluoro-phenyl)-3-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-thiourea (380304-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 60.88 g / ethyl chloroformate / H₂O / 0.67 h / 35 - 40 °C

2: 58 percent / ethyl acetate / 12 h / Heating

With chloroformic acid ethyl ester; In water; ethyl acetate;

DOI:10.1021/jf010632k

upstream raw materials:

2,4-difluorophenyl isothiocyanate

2-amino-2-hydroxymethyl-1,3-propanediol

2,4-difluorophenylamine