[(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester

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Chemical Name:[(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester
CAS No.:1433280-54-6
Molecular Formula:C₂₃H₂₉BrN₄O₄
Molecular Weight:505.412
Hs Code.:

Synonyms:[(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester

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Chemical Property of [(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester

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Technology Process of [(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester

There total 5 articles about [(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1009120-03-9
(S)-methoxycarbonylamino(tetrahydropyran-4-yl)acetic acid

: 4-(4-bromo-phenyl)-2-((2S,4S)-4-methyl-pyrrolidin-2-yl)-1H-imidazole hydrochloride

: 1433280-54-6
[(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl acetamide; at 20 ℃; for 1h;

Reference yield:

: 811842-25-8,475649-32-2
(S)-2-amino-2-(tetrahydro-2 H-pyran-4-yl)acetic acid

: 1433280-54-6
[(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water

1.2: 0.5 h

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 20 °C

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl acetamide; water;

Reference yield:

: 1250939-42-4
(2-(2-(4-bromophenyl)-2-oxoethyl)) 1-(tert-butyl) (2S,4S)-4-methylpyrrolidine-1,2-dicarboxylate

: 1433280-54-6
[(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / toluene / 95 °C

2: hydrogenchloride / 1,4-dioxane; ethyl acetate

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 20 °C

With hydrogenchloride; ammonium acetate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl acetamide; ethyl acetate; toluene;