(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide

Base Information

Chemical Name:(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide
CAS No.:1239670-11-1
Molecular Formula:C₂₅H₂₁F₄N₃O₅S₂
Molecular Weight:583.584
Hs Code.:

Synonyms:(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide

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Chemical Property of (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide

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Technology Process of (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide

There total 9 articles about (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1239670-12-2
(S)-2-amino-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl propanamide

: 98-59-9
p-toluenesulfonyl chloride

: 1239670-11-1
(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide

Guidance literature:: With pyridine; at 50 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ml3000269

Reference yield:

: 87310-69-8
N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide

: 1239670-11-1
(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 40 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Inert atmosphere

2.2: -45 - -20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol; diethyl ether / -5 - 20 °C / Inert atmosphere

4.1: pyridine / 5 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; In tetrahydrofuran; methanol; diethyl ether; hexane;
DOI:10.1021/ml3000269

Reference yield:

: 1239669-98-7
S(S)-2-(tert-butylsulfinylimino)-N-(4-cyano-3-(trifluoromethyl)phenyl) propanamide

: 1239670-11-1
(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Inert atmosphere

1.2: -45 - -20 °C / Inert atmosphere

2.1: hydrogenchloride / methanol; diethyl ether / -5 - 20 °C / Inert atmosphere

3.1: pyridine / 5 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; n-butyllithium; In tetrahydrofuran; methanol; diethyl ether; hexane;
DOI:10.1021/ml3000269