5-[(R)-3-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

Base Information

Chemical Name:5-[(R)-3-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one
CAS No.:1354817-68-7
Molecular Formula:C₂₃H₂₃NO₄S
Molecular Weight:409.506
Hs Code.:

Synonyms:5-[(R)-3-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

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Chemical Property of 5-[(R)-3-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

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Technology Process of 5-[(R)-3-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

There total 11 articles about 5-[(R)-3-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1354812-23-9
(R)-5-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-1-methylpyridin-2(1H)-one

: 20277-69-4
sodium methansulfinate

: 1354817-68-7
5-[(R)-3-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

Guidance literature:: With copper(l) iodide; L-proline; sodium hydroxide; In dimethyl sulfoxide; at 120 ℃; for 26h;

Reference yield:

: 1354808-43-7
3-(4-bromophenyl)-3-o-tolylpropanoic acid

: 1354817-68-7
5-[(R)-3-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.08 h

1.2: 17 h / 20 °C

2.1: Reprosil Chiral-NR / n-heptane; isopropyl alcohol / Resolution of racemate

3.1: n-butyllithium / tetrahydrofuran; hexane / 1.67 h / -75 - -70 °C

3.2: 1 h / -75 - -70 °C

4.1: water; hydrogenchloride / 1,4-dioxane / 1.75 h / 100 °C

5.1: potassium carbonate / N,N-dimethyl acetamide / 17 h / 20 °C

6.1: sodium hydroxide; L-proline / dimethyl sulfoxide / 26 h / 120 °C

With hydrogenchloride; n-butyllithium; water; potassium carbonate; 1,1'-carbonyldiimidazole; L-proline; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; n-heptane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1354808-42-6
ethyl 3-(4-bromophenyl)-2-cyano-3-o-tolylpropanoate

: 1354817-68-7
5-[(R)-3-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; acetic acid / 20 h / 27 °C / Reflux

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.08 h

2.2: 17 h / 20 °C

3.1: Reprosil Chiral-NR / n-heptane; isopropyl alcohol / Resolution of racemate

4.1: n-butyllithium / tetrahydrofuran; hexane / 1.67 h / -75 - -70 °C

4.2: 1 h / -75 - -70 °C

5.1: water; hydrogenchloride / 1,4-dioxane / 1.75 h / 100 °C

6.1: potassium carbonate / N,N-dimethyl acetamide / 17 h / 20 °C

7.1: sodium hydroxide; L-proline / dimethyl sulfoxide / 26 h / 120 °C

With hydrogenchloride; n-butyllithium; sulfuric acid; water; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; L-proline; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; n-heptane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; isopropyl alcohol;