(+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate

Base Information

Chemical Name:(+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate
CAS No.:174609-79-1
Molecular Formula:C₂₆H₃₀N₆O₂
Molecular Weight:458.563
Hs Code.:

Synonyms:(+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate

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Chemical Property of (+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate

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Technology Process of (+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate

There total 4 articles about (+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 37167-62-7,3042-81-7,61139-20-6
bromo-phenyl-acetic acid methyl ester

: 174609-58-6
1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]-4H-piperazine

: 174609-79-1
(+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1.5h;
DOI:10.1021/jm980569z

Reference yield: 70.0%

: 174609-79-1
(+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate

Guidance literature:

Reference yield:

: 78643-42-2
5-bromopentanal dimethyl acetal

: 174609-79-1
(+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaI, Na₂CO₃ / 1,2-dimethoxy-ethane / 3 h / 100 °C

2: 44 percent / 4 percent H₂SO₄ / 48 h / Heating

3: 70 percent / K₂CO₃ / dimethylformamide / 1.5 h / 60 °C

With sulfuric acid; sodium carbonate; potassium carbonate; sodium iodide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980569z