METHYL ALPHA-BROMOPHENYLACETATE

Base Information

• Chemical Name: METHYL ALPHA-BROMOPHENYLACETATE
• CAS No.: 37167-62-7
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.073
• Hs Code.: 2916399090
• Mol file: 37167-62-7.mol

Synonyms:Methyl a-bromobenzeneacetate;methyl bromo(phenyl)acetate;Acetic acid, bromophenyl-, methyl ester;benzeneacetic acid, α-bromo-, methyl ester;Methyl α-bromophenylacetate;

Chemical Property of METHYL ALPHA-BROMOPHENYLACETATE

Chemical Property:

• Refractive Index: n20/D 1.554
• Boiling Point: 273.3 °C at 760 mmHg
• Flash Point: 105.4 °C
• PSA: 26.30000
• Density: 1.466 g/cm³
• LogP: 2.29560
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methylalpha-bromophenylacetate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL ALPHA-BROMOPHENYLACETATE

There total 25 articles about METHYL ALPHA-BROMOPHENYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + 2-bromophenylacetic acid (4870-65-9,31302-84-8) → bromo-phenyl-acetic acid methyl ester (37167-62-7,3042-81-7,61139-20-6)

Guidance literature:

With sulfuric acid; for 1h; Reflux;

DOI:10.1021/acs.macromol.0c01697

Reference yield: 93.27%

methanol (67-56-1) + phenylacetic acid (103-82-2) → bromo-phenyl-acetic acid methyl ester (37167-62-7,3042-81-7,61139-20-6)

Guidance literature:

phenylacetic acid; With thionyl chloride; at 35 - 40 ℃; for 4.5h;

With bromine; iodine; at 85 - 90 ℃; for 6.5h;

methanol; at 60 ℃; for 1h;

DOI:10.1016/j.bioorg.2019.102930

Reference yield: 90.0%

benzeneacetic acid methyl ester (101-41-7) → bromo-phenyl-acetic acid methyl ester (37167-62-7,3042-81-7,61139-20-6)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In chloroform; Reflux;

DOI:10.1016/j.bmcl.2014.10.031

upstream raw materials:

methanol

bromo(phenyl)acetyl chloride

phenylacetic acid

1,1-dimethoxy-2-phenylethene

Downstream raw materials:

methyl 2-phenyl-2-(piperidin-1-yl)acetate

(2,5-dimethyl-4-oxo-piperidino)-phenyl-acetic acid methyl ester

(2-methoxycarbonyl-ethylsulfanyl)-phenyl-acetic acid methyl ester

methyl α-(N,N-dimethylamino)phenylacetate