Methyl 2-bromomethyl-3-methoxybenzoate

Base Information

• Chemical Name: Methyl 2-bromomethyl-3-methoxybenzoate
• CAS No.: 71887-28-0
• Molecular Formula: C10H11BrO3
• Molecular Weight: 259.1
• Hs Code.: 2918990090
• Mol file: 71887-28-0.mol

Synonyms:2-Bromomethyl-3-methoxybenzoicacid methyl ester;Methyl 2-(bromomethyl)-3-methoxybenzoate;

Chemical Property of Methyl 2-bromomethyl-3-methoxybenzoate

Chemical Property:

• Vapor Pressure: 0.000171mmHg at 25°C
• Melting Point: 112-114 °C(Solv: hexane (110-54-3))
• Refractive Index: 1.547
• Boiling Point: 330 °C at 760 mmHg
• Flash Point: 153.4 °C
• PSA: 35.53000
• Density: 1.432 g/cm³
• LogP: 2.37670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-bromomethyl-3-methoxy-benzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-bromomethyl-3-methoxybenzoate

There total 3 articles about Methyl 2-bromomethyl-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-methoxy-2-methylbenzoic acid methyl ester (42981-93-1) → methyl 2-(bromomethyl)-3-methoxybenzoate (71887-28-0)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In chloroform; for 15h; Reflux;

DOI:10.1016/j.tet.2017.11.035

Reference yield:

3-methoxy-2-methylbenzoic acid (55289-06-0) → methyl 2-(bromomethyl)-3-methoxybenzoate (71887-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 6 h / Reflux

2: N-Bromosuccinimide; 2-(4-biphenylyl)-5-phenyloxazole / tetrachloromethane / 80 °C

With N-Bromosuccinimide; thionyl chloride; 2-(4-biphenylyl)-5-phenyloxazole; In tetrachloromethane;

DOI:10.1016/j.cclet.2011.10.002

Reference yield:

3-hydroxy 2-methylbenzoic acid (603-80-5) → methyl 2-(bromomethyl)-3-methoxybenzoate (71887-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Inert atmosphere; Reflux

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; In tetrachloromethane;

DOI:10.1002/ejic.201001092

upstream raw materials:

3-methoxy-2-methylbenzoic acid methyl ester

3-hydroxy 2-methylbenzoic acid

3-methoxy-2-methylbenzoic acid

Downstream raw materials:

methyl 2-(2,5-dimethoxy-4-methylbenzyl)-3-methoxybenzoate

2-(2,5-Bis-benzyloxy-4-methyl-benzyl)-3-methoxy-benzoic acid methyl ester

methyl (S)-3-methoxy-2-<<2'-(methoxymethyl)pyrrolidinyl>methyl>benzoate

4-methoxyisoindolin-1-one