3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine

Base Information

• Chemical Name: 3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine
• CAS No.: 1446526-83-5
• Molecular Formula: C₃₂H₃₂N₂O₆S
• Molecular Weight: 572.682
• Mol file: 1446526-83-5.mol

Synonyms:3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine

Chemical Property of 3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine

There total 1 articles about 3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-threo-pentofuranosyl)thymine (104218-44-2) + Methyl thioglycolate (2365-48-2) → 3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine (1446526-83-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.05.047

Reference yield: 77.0%

3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine (1446526-83-5) → 3′-deoxy-3′-S-[(methoxycarbonyl)methylsulfonyl]-5′-O-tritylthymidine (1446526-87-9)

Guidance literature:

With magnesium bis(monoperoxyphthalate)hexahydrate; In methanol; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c9ob01250h

Reference yield: 74.0%

3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine (1446526-83-5) → 3′-deoxy-3′-S-[(carboxymethyl)thio]-5′-O-tritylthymidine (1446526-84-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2013.05.047

upstream raw materials:

1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-threo-pentofuranosyl)thymine

Methyl thioglycolate

Downstream raw materials:

3′-deoxy-3′-S-[(carboxymethyl)thio]-5′-O-tritylthymidine

3′-deoxy-3′-S-[(methoxycarbonyl)methylsulfonyl]-5′-O-tritylthymidine