methyl 2-(4-(4-methoxybenzyl(methyl)amino)phenyl)-2-phenylacetate

Base Information

• Chemical Name: methyl 2-(4-(4-methoxybenzyl(methyl)amino)phenyl)-2-phenylacetate
• CAS No.: 1262227-17-7
• Molecular Formula: C₂₄H₂₅NO₃
• Molecular Weight: 375.467
• Mol file: 1262227-17-7.mol

Synonyms:methyl 2-(4-(4-methoxybenzyl(methyl)amino)phenyl)-2-phenylacetate

Chemical Property of methyl 2-(4-(4-methoxybenzyl(methyl)amino)phenyl)-2-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-(4-(4-methoxybenzyl(methyl)amino)phenyl)-2-phenylacetate

There total 2 articles about methyl 2-(4-(4-methoxybenzyl(methyl)amino)phenyl)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Methyl phenyldiazoacetate (22979-35-7) + 4-methoxy-N-methyl-N-phenylbenzenemethanamine (37931-52-5) → methyl 2-(4-(4-methoxybenzyl(methyl)amino)phenyl)-2-phenylacetate (1262227-17-7)

Guidance literature:

With copper acetylacetonate; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.07.070

Reference yield:

p-methoxybenzyl chloride (824-94-2) + N-methylaniline (100-61-8) → methyl 2-(4-(4-methoxybenzyl(methyl)amino)phenyl)-2-phenylacetate (1262227-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 5 h / Reflux

2: copper acetylacetonate; boron trifluoride diethyl etherate / dichloromethane / 6 h / 20 °C / Inert atmosphere

With copper acetylacetonate; boron trifluoride diethyl etherate; potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/j.tetlet.2012.07.070

upstream raw materials:

Methyl phenyldiazoacetate

4-methoxy-N-methyl-N-phenylbenzenemethanamine

p-methoxybenzyl chloride

N-methylaniline