4-methoxy-N-methyl-N-phenylbenzenemethanamine

Base Information

• Chemical Name: 4-methoxy-N-methyl-N-phenylbenzenemethanamine
• CAS No.: 37931-52-5
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.306
• Mol file: 37931-52-5.mol

Synonyms:4-methoxy-N-methyl-N-phenylbenzenemethanamine

Chemical Property of 4-methoxy-N-methyl-N-phenylbenzenemethanamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-methoxy-N-methyl-N-phenylbenzenemethanamine

There total 16 articles about 4-methoxy-N-methyl-N-phenylbenzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Methoxybenzyl alcohol (105-13-5) + N-methylaniline (100-61-8) → 4-methoxy-N-methyl-N-phenylbenzenemethanamine (37931-52-5)

Guidance literature:

With (9-borabicyclo[3.3.1]nonanyl)ethyl(diphenyl)phosphine; palladium diacetate; In para-xylene; for 24h; Molecular sieve; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.152537

Reference yield: 98.0%

p-methoxybenzyl chloride (824-94-2) + N-methyl-N-phenylformamide (93-61-8) → 4-methoxy-N-methyl-N-phenylbenzenemethanamine (37931-52-5)

Guidance literature:

With NHC-Pd(II)-Im; sodium hydroxide; In water; at 50 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.3184/174751913X13787959859344

Reference yield: 93.0%

para-iodoanisole (696-62-8) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → 4-methoxy-N-methyl-N-phenylbenzenemethanamine (37931-52-5)

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; potassium hydroxide; In N,N-dimethyl-formamide; at 23 ℃; Irradiation;

DOI:10.1126/science.1255525

upstream raw materials:

p-Methoxybenzyl bromide

N-methylaniline

4-methoxybenzoic acid

p-methoxybenzyl chloride

Downstream raw materials:

N-phenyl-N-methylcarbamoyl chloride

p-methoxybenzyl chloride

methyl 2-(4-(4-methoxybenzyl(methyl)amino)phenyl)-2-phenylacetate

4,4'-methylenebis(N-(4-methoxybenzyl)-N-methylaniline)