(R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate

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Chemical Name:(R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate
CAS No.:1402466-09-4
Molecular Formula:C₂₉H₂₈N₄O₄
Molecular Weight:496.566
Hs Code.:

Synonyms:(R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate

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Chemical Property of (R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate

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Technology Process of (R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate

There total 4 articles about (R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159489-46-9
[4-(1'-carboxycyclopropyl)phenyl]boronic acid

: 1402465-88-6
(R)-1-phenylethyl (4-(5-bromopyridin-2-yl)-1-methyl-1H-pyrazol-5-yl)carbamate

: 1402466-09-4
(R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 95 ℃; for 3h; sealed tube;

Reference yield:

: 312325-72-7
2-(5-bromopyridin-2-yl)acetonitrile

: 1402466-09-4
(R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic anhydride / 18 h / 125 °C

2.1: ethanol / 2 h / Reflux

3.1: triethylamine / dichloromethane; toluene / 1 h / 0 °C

3.2: 18 h / 20 - 45 °C / Sealed vessel

4.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 95 °C / sealed tube

With acetic anhydride; sodium hydrogencarbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1402465-86-4
2-(5-bromopyridin-2-yl)-3-ethoxyacrylonitrile

: 1402466-09-4
(R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 2 h / Reflux

2.1: triethylamine / dichloromethane; toluene / 1 h / 0 °C

2.2: 18 h / 20 - 45 °C / Sealed vessel

3.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 95 °C / sealed tube

With sodium hydrogencarbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;