4-(1'-CARBOXYL-CYCLOPROPYL)PHENYLBORONIC ACID

Base Information

• Chemical Name: 4-(1'-CARBOXYL-CYCLOPROPYL)PHENYLBORONIC ACID
• CAS No.: 1159489-46-9
• Molecular Formula: C10H11BO4
• Molecular Weight: 206.006
• Hs Code.: 2931900090
• Mol file: 1159489-46-9.mol

Synonyms:4-(1'-CARBOXYL-CYCLOPROPYL)PHENYLBORONIC ACID;1-(4-Boronophenyl)cyclopropanecarboxylic acid;4-(1-Carboxycyclopropyl)phenylboronic acid;1-(4-boronophenyl)cyclopropane-1-carboxylicacid

Chemical Property of 4-(1'-CARBOXYL-CYCLOPROPYL)PHENYLBORONIC ACID

Chemical Property:

• Boiling Point: 445.1±55.0 °C(Predicted)
• PKA: 4.23±0.20(Predicted)
• PSA: 77.76000
• Density: 1.38±0.1 g/cm3(Predicted)
• LogP: -0.51740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(1-Carboxycyclopropyl)phenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1'-CARBOXYL-CYCLOPROPYL)PHENYLBORONIC ACID

There total 1 articles about 4-(1'-CARBOXYL-CYCLOPROPYL)PHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrahydroxydiboron (13675-18-8) + 1-(4-bromophenyl)cyclopropanecarboxylic acid (345965-52-8) → [4-(1'-carboxycyclopropyl)phenyl]boronic acid (1159489-46-9)

Guidance literature:

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; at 50 ℃; Large scale;

DOI:10.1021/acs.oprd.7b00301

Reference yield: 70.0%

[4-(1'-carboxycyclopropyl)phenyl]boronic acid (1159489-46-9) + orthoformic acid triethyl ester (122-51-0) → C12H15BO4

Guidance literature:

With sulfuric acid; In ethanol; toluene; at 80 ℃;

DOI:10.1021/acs.oprd.7b00301

Reference yield:

[4-(1'-carboxycyclopropyl)phenyl]boronic acid (1159489-46-9) + (R)-1-phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate (1228690-37-6) → (R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid (1257213-50-5)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 80 ℃; for 2h; Inert atmosphere; Sealed tube;

upstream raw materials:

tetrahydroxydiboron

1-(4-bromophenyl)cyclopropanecarboxylic acid

Downstream raw materials:

1-[4'-((1S)-1-{[(1S)-1-({[(1S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl]amino}carbonyl)-2-methylpropyl]amino}-2,2,2-trifluoroethyl)biphenyl-4-yl]cyclopropanecarboxylic acid

(R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid

1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

(R)-methyl 1-(4-(6-(1-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)pyridin-3-yl)phenyl)cyclopropanecarboxylate

Refernces