Technology Process of N-benzyloxycarbonyl-L-leucine trimethylsilylethyl ester
There total 1 articles about N-benzyloxycarbonyl-L-leucine trimethylsilylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
for 14h;
Inert atmosphere;
DOI:10.3390/molecules23112868
- Guidance literature:
-
Multi-step reaction with 12 steps
1: H2 / Pd/C
2: 71 percent / HOBt, DCC / 0 °C
3: H2 / 10percent Pd/C / propan-2-ol
4: 76 percent / DMAP, DCC / 0 °C
5: 90 percent / Bu4N(1+)*F(1-) / Ambient temperature
6: 40 percent / HOBt, EDC / 0 °C
7: 95 percent / Bu4N(1+)*F(1-) / Ambient temperature
8: 99 percent / TFA-OH / 0 °C
9: 18 percent / NMM, HOBt, EDC / Ambient temperature
10: 88 percent / H2 / 10percent Pd/C
12: H2 / Pd/C
With
4-methyl-morpholine; dmap; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
isopropyl alcohol;
DOI:10.1021/ja00256a046
- Guidance literature:
-
Multi-step reaction with 9 steps
1: H2 / Pd/C
2: 71 percent / HOBt, DCC / 0 °C
3: H2 / 10percent Pd/C / propan-2-ol
4: 84 percent / DMAP, DCC / 0 °C
5: 95 percent / Bu4N(1+)*F(1-) / Ambient temperature
6: 56 percent / HOBt, EDC / 0 °C
7: 95 percent / Bu4N(1+)*F(1-) / Ambient temperature
8: 99 percent / TFA-OH / 0 °C
9: 8 percent / NMM, HOBt, EDC / Ambient temperature
With
4-methyl-morpholine; dmap; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
isopropyl alcohol;
DOI:10.1021/ja00256a046
