N-(cyclopropyl)-4-fluorobenzimidoyl chloride

Base Information

• Chemical Name: N-(cyclopropyl)-4-fluorobenzimidoyl chloride
• CAS No.: 1192139-71-1
• Molecular Formula: C₁₀H₉ClFN
• Molecular Weight: 197.64
• Mol file: 1192139-71-1.mol

Synonyms:N-(cyclopropyl)-4-fluorobenzimidoyl chloride

Chemical Property of N-(cyclopropyl)-4-fluorobenzimidoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(cyclopropyl)-4-fluorobenzimidoyl chloride

There total 2 articles about N-(cyclopropyl)-4-fluorobenzimidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

N-cyclopropyl-4-fluorobenzamide (88229-16-7) → N-(cyclopropyl)-4-fluorobenzimidoyl chloride (1192139-71-1)

Guidance literature:

With thionyl chloride; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1134/S1070363215020115

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → N-(cyclopropyl)-4-fluorobenzimidoyl chloride (1192139-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: thionyl chloride / 2 h / 100 °C / Inert atmosphere

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1134/S1070363215020115

Reference yield: 62.0%

1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) + N-(cyclopropyl)-4-fluorobenzimidoyl chloride (1192139-71-1) → N'-cyclopropyl-4-fluoro-N-(5-methyl-2-phenyl-2H-pyrazol-3-yl)benzamidine (1006463-59-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 40 ℃; for 5h;

DOI:10.1055/s-0033-1340158

upstream raw materials:

N-cyclopropyl-4-fluorobenzamide

4-fluorobenzoyl chloride

Downstream raw materials:

N'-cyclopropyl-4-fluoro-N-(5-methyl-2-phenyl-2H-pyrazol-3-yl)benzamidine

N'-cyclopropyl-4-fluoro-N-(2-isopropyl-2H-pyrazol-3-yl)benzamidine

5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1,4-diphenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine

5-cyclopropyl-6-(4-fluorophenyl)-4-(4-methoxyphenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine