C₁₈H₁₅BrClFN₂O₃

Base Information

Chemical Name:C₁₈H₁₅BrClFN₂O₃
CAS No.:1089178-99-3
Molecular Formula:C₁₈H₁₅BrClFN₂O₃
Molecular Weight:441.684
Hs Code.:

C<sub>18</sub>H<sub>15</sub>BrClFN<sub>2</sub>O<sub>3</sub>

Synonyms:C₁₈H₁₅BrClFN₂O₃

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Chemical Property of C₁₈H₁₅BrClFN₂O₃

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Technology Process of C₁₈H₁₅BrClFN₂O₃

There total 7 articles about C₁₈H₁₅BrClFN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1089178-98-2
C₂₃H₂₃BrClFN₂O₅

: 1089178-99-3
C₁₈H₁₅BrClFN₂O₃

Guidance literature:: C₂₃H₂₃BrClFN₂O₅; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 5h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 473923-96-5
3-chloro-5-methoxybenzonitrile

: 1089178-99-3
C₁₈H₁₅BrClFN₂O₃

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,4,6-trimethyl-pyridine; lithium iodide / 4 h / 170 °C

1.2: 20 °C

2.1: sodium hydride / ISOPROPYLAMIDE / 0.5 h / 50 °C

2.2: 2 h / 125 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran; toluene / 1 h / -78 °C

3.2: 2 h / -50 °C

3.3: -78 - 20 °C

4.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 20 °C

5.1: phosphorus tribromide / dichloromethane / 24 h / 20 °C

6.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

6.2: 4 h / -78 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 5 h / 0 °C

With 2,4,6-trimethyl-pyridine; sodium tetrahydroborate; n-butyllithium; isopropylmagnesium chloride; phosphorus tribromide; sodium hydride; diisopropylamine; trifluoroacetic acid; lithium iodide; In tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE; toluene;

Reference yield:

: 473923-97-6
3-chloro-5-hydroxybenzonitrile

: 1089178-99-3
C₁₈H₁₅BrClFN₂O₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / ISOPROPYLAMIDE / 0.5 h / 50 °C

1.2: 2 h / 125 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran; toluene / 1 h / -78 °C

2.2: 2 h / -50 °C

2.3: -78 - 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 20 °C

4.1: phosphorus tribromide / dichloromethane / 24 h / 20 °C

5.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

5.2: 4 h / -78 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 5 h / 0 °C

With sodium tetrahydroborate; n-butyllithium; isopropylmagnesium chloride; phosphorus tribromide; sodium hydride; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE; toluene;