3-(4-Methoxyphenyl)propan-1-amine hydrochloride

Base Information

• Chemical Name: 3-(4-Methoxyphenyl)propan-1-amine hydrochloride
• CAS No.: 36397-51-0
• Molecular Formula: C10H16ClNO
• Molecular Weight: 201.696
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID40388692
• Mol file: 36397-51-0.mol

Synonyms:36397-51-0;3-(4-methoxyphenyl)propan-1-amine hydrochloride;3-(4-Methoxy-phenyl)-propylamine hydrochloride;3-(4-Methoxyphenyl)propylamine HCl;3-(4-methoxyphenyl)propan-1-amine;hydrochloride;3-(4-Methoxy-phenyl)-propylamine, HCl;3-(4-Methoxy-phenyl)-propylaminehydrochloride;3-(4-methoxyphenyl)propan-1-amine,hydrochloride;SCHEMBL1029559;DTXSID40388692;MFCD09991708;AKOS015849079;SB77580;AS-38108;A6294;FT-0718230;[3-(4-methoxyphenyl)propyl]amine hydrochloride;3-(4-methoxyphenyl)propan-1-aminehydrochloride;EN300-316390;3-(4-Methoxy-phenyl)-propylamine;Q-102399;3-(4-Methoxyphenyl)propan-1-amine--hydrogen chloride (1/1)

Chemical Property of 3-(4-Methoxyphenyl)propan-1-amine hydrochloride

Chemical Property:

• Boiling Point: 266 °C at 760 mmHg
• Flash Point: 113.8 °C
• PSA: 35.25000
• LogP: 3.08880
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 201.0920418
• Heavy Atom Count: 13
• Complexity: 108

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Methoxyphenyl)propylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CCCN.Cl

Technology Process of 3-(4-Methoxyphenyl)propan-1-amine hydrochloride

There total 2 articles about 3-(4-Methoxyphenyl)propan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-(4-methoxyphenyl)propyl bromide (57293-19-3) → 3-(4-methoxyphenyl)propan-1-amine hydrogen chloride (36397-51-0)

Guidance literature:

3-(4-methoxyphenyl)propyl bromide; With magnesium; Inert atmosphere;

With 3,3’-di-tert-butyl oxaziridine; In diethyl ether; at 20 ℃; for 6h; Inert atmosphere;

With hydrogenchloride; In water; at 0 ℃;

DOI:10.1021/acs.orglett.8b03734

Reference yield:

C18H23NO → 3-(4-methoxyphenyl)propan-1-amine hydrogen chloride (36397-51-0)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; water; at 65 ℃; for 14h;

DOI:10.1016/j.tetlet.2009.02.129

Reference yield: 89.0%

3-(4-methoxyphenyl)propan-1-amine hydrogen chloride (36397-51-0) + trifluoroacetic acid (76-05-1) → 2,2,2-trifluoro-N-(3-(4-methoxyphenyl)propyl)acetamide (144818-69-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

3-(4-methoxyphenyl)propyl bromide

Downstream raw materials:

2,2,2-trifluoro-N-(3-(4-methoxyphenyl)propyl)acetamide

Refernces

• 1、 Lamb, Gareth W.,Watson, Andrew J.A.,Jolley, Katherine E.,Maxwell, Aoife C.,Williams, Jonathan M.J.. "Borrowing hydrogen methodology for the conversion of alcohols into N-protected primary amines and in situ deprotection". experimental part. p. 3374 - 3377. Retrieved 2009/09/05.