3-[3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylphenoxy)phenyl]propylphosphonic acid

Base Information

Chemical Name:3-[3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylphenoxy)phenyl]propylphosphonic acid
CAS No.:852948-94-8
Molecular Formula:C₂₀H₂₇O₅P
Molecular Weight:378.405
Hs Code.:

Synonyms:3-[3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylphenoxy)phenyl]propylphosphonic acid

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Chemical Property of 3-[3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylphenoxy)phenyl]propylphosphonic acid

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Technology Process of 3-[3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylphenoxy)phenyl]propylphosphonic acid

There total 7 articles about 3-[3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylphenoxy)phenyl]propylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 852948-99-3
diethyl 3-[3,5-dimethyl-4-(3'-iso-propyl-4'-methoxyphenoxy)phenyl]propylphosphonate

: 852948-94-8
3-[3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylphenoxy)phenyl]propylphosphonic acid

Guidance literature:: diethyl 3-[3,5-dimethyl-4-(3'-iso-propyl-4'-methoxyphenoxy)phenyl]propylphosphonate; With trimethylsilyl bromide; In dichloromethane; at -30 - 20 ℃; for 16h;

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 19h;

With water; In dichloromethane; at 0 ℃;

Reference yield:

: C₂₁H₂₉O₅P

: 852948-94-8
3-[3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylphenoxy)phenyl]propylphosphonic acid

Guidance literature:: C₂₁H₂₉O₅P; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 19h;

With hydrogenchloride; In water;

Reference yield:

: 322472-55-9
3,5-dimethyl-4-(3'-iso-propyl-4'-methoxyphenoxy)benzaldehyde

: 852948-94-8
3-[3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylphenoxy)phenyl]propylphosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C

4.1: carbon tetrabromide; triphenylphosphine / diethyl ether / 16 h / 20 °C

5.1: N,N-dimethyl-formamide / 2.5 h / Heating / reflux

6.1: trimethylsilyl bromide / dichloromethane / 16 h / -30 - 20 °C

7.1: boron tribromide / dichloromethane / 19 h / -78 - 20 °C

With trimethylsilyl bromide; carbon tetrabromide; hydrogen; boron tribromide; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;