((S)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptyl ester

Base Information

Chemical Name:((S)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptyl ester
CAS No.:92803-72-0
Molecular Formula:C₂₄H₄₃NO₃Si
Molecular Weight:421.696
Hs Code.:

Synonyms:((S)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptyl ester

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Chemical Property of ((S)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptyl ester

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Technology Process of ((S)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptyl ester

There total 10 articles about ((S)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 92803-69-5,92934-87-7
((R)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-hydroxy-2,6-dimethyl-heptyl ester

: 92803-72-0
((R)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptyl ester

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 25 ℃;
DOI:10.1139/v84-267

Reference yield: 96.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 92934-87-7
((S)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-hydroxy-2,6-dimethyl-heptyl ester

: 92803-72-0
((S)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptyl ester

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; for 1.5h; Ambient temperature;

Reference yield:

: 92803-65-1
(S)-2-[(1S,3R)-2,2-Dibromo-3-((R)-2-hydroxy-1-methyl-ethyl)-cyclopropyl]-propan-1-ol

: 92803-72-0
((R)-1-Phenyl-ethyl)-carbamic acid (2S,6R)-7-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / triethylamine / CH₂Cl₂ / 10 h

2: 1.) n-BuLi / 1.) ether; 2.) THF, -78 deg C, 30 min

3: 99 percent / methyllithium / diethyl ether / -35 °C

4: H₂ / PtO₂ / methanol

5: 96 percent / imidazole / tetrahydrofuran / 25 °C

With 1H-imidazole; n-butyllithium; methyllithium; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1139/v84-267