1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel

Base Information

• Chemical Name: 1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel
• CAS No.: 164735-02-8
• Molecular Formula: C₆₁H₈₁NO₁₄S₂Si₂
• Molecular Weight: 1172.62

Synonyms:1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel

Chemical Property of 1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel

Chemical Property:

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Technology Process of 1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel

There total 1 articles about 1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + 1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate] (135365-62-7) + methyl iodide (74-88-4) → 1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel (164735-02-8)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, r.t., 5 min, 2.) r.t., 30 min;

DOI:10.1021/jo00115a050

Reference yield: 90.0%

1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel (164735-02-8) → 1-Benzoyl-2-debenzoyl-2-<(S-methyldithio)carbonyl>paclitaxel

Guidance literature:

With hydrogenchloride; for 0.5h; Ambient temperature;

DOI:10.1021/jo00115a050

Reference yield: 79.0%

1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel (164735-02-8) → 1-Benzoyl-2-des(benzoyloxy)-2',7-bis(triethylsilyl)paclitaxel

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 1h; Heating;

DOI:10.1021/jo00115a050

upstream raw materials:

carbon disulfide

1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate]

methyl iodide

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