7-amino-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

Base Information

Chemical Name:7-amino-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one
CAS No.:1442470-75-8
Molecular Formula:C₁₆H₁₄ClFN₄O
Molecular Weight:332.765
Hs Code.:

Synonyms:7-amino-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

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Chemical Property of 7-amino-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

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Technology Process of 7-amino-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

There total 12 articles about 7-amino-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1012878-91-9
3-(5-amino-2-chloro-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

: 1442470-75-8
7-amino-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 150 °C

2: sodium hydrogencarbonate

3: trifluoroacetic acid / 60 °C

With sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1442470-75-8
7-amino-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 0.17 h / 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 150 °C

5: sodium hydrogencarbonate

6: trifluoroacetic acid / 60 °C

With manganese(IV) oxide; aluminum oxide; potassium fluoride; lithium aluminium tetrahydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 959162-99-3
(6-chloro-4-(ethylamino)pyridin-3-yl)methanol

: 1442470-75-8
7-amino-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 0.17 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 150 °C

4: sodium hydrogencarbonate

5: trifluoroacetic acid / 60 °C

With manganese(IV) oxide; aluminum oxide; potassium fluoride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide;