C₂₀H₁₈ClN₅O₄

Base Information

Chemical Name:C₂₀H₁₈ClN₅O₄
CAS No.:1609531-06-7
Molecular Formula:C₂₀H₁₈ClN₅O₄
Molecular Weight:427.847
Hs Code.:

C<sub>20</sub>H<sub>18</sub>ClN<sub>5</sub>O<sub>4</sub>

Synonyms:C₂₀H₁₈ClN₅O₄

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Chemical Property of C₂₀H₁₈ClN₅O₄

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Technology Process of C₂₀H₁₈ClN₅O₄

There total 4 articles about C₂₀H₁₈ClN₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 6937-03-7
methyl 2-aminoisonicotinate

: 1609531-05-6
C₁₄H₁₃Cl₂N₃O₂

: 1609531-06-7
C₂₀H₁₈ClN₅O₄

Guidance literature:: methyl 2-aminoisonicotinate; C₁₄H₁₃Cl₂N₃O₂; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; at 145 ℃; for 1h; Inert atmosphere;

With water; sodium hydroxide; In N,N-dimethyl acetamide; at 20 - 60 ℃;

Reference yield:

: 93-50-5
4-chloro-o-anisidine

: 1609531-06-7
C₂₀H₁₈ClN₅O₄

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl acetamide / 0.33 h

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl acetamide / 1 h / 145 °C / Inert atmosphere

2.2: 20 - 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 73027-79-9
4,6-dichloro-nicotinic acid

: 1609531-06-7
C₂₀H₁₈ClN₅O₄

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl acetamide / 0.33 h

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl acetamide / 1 h / 145 °C / Inert atmosphere

3.2: 20 - 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; oxalyl dichloride; sodium hexamethyldisilazane; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; chloroform; N,N-dimethyl acetamide; N,N-dimethyl-formamide;