Technology Process of (2R,5R)-N-Benzoyl-2,5-bis<4-(benzyloxy)butyl>pyrrolidine
There total 9 articles about (2R,5R)-N-Benzoyl-2,5-bis<4-(benzyloxy)butyl>pyrrolidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
dichloromethane;
for 0.166667h;
DOI:10.1021/jo00004a011
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 20percent KOH / methanol / 1 h / ice bath
2: 62 percent / CuI / tetrahydrofuran / 1.5 h / -15 °C
3: 1.) SOCl2, Et3N, 2.) NaIO4, RuCl3*xH2O / 1.) CH2Cl2, ice bath, 30 min 2.) CCl4-MeCN, 0 deg C, 2h
4: 1.) LiN3, 2.) H2SO4, H2O / 1.)DMF, r.t., 30 min 2.) THF, r.t., 1 h
5: 91 percent / Et3N / CH2Cl2
6: 99 percent / H2 / 5percent Pd-BaSO4 / methanol
7: 73 percent / K2CO3 / CH2Cl2 / 0.17 h
With
ruthenium trichloride; potassium hydroxide; sodium periodate; copper(l) iodide; thionyl chloride; lithium azide; sulfuric acid; water; hydrogen; potassium carbonate; triethylamine;
palladium on barium sulfate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00004a011
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 62 percent / CuI / tetrahydrofuran / 1.5 h / -15 °C
2: 1.) SOCl2, Et3N, 2.) NaIO4, RuCl3*xH2O / 1.) CH2Cl2, ice bath, 30 min 2.) CCl4-MeCN, 0 deg C, 2h
3: 1.) LiN3, 2.) H2SO4, H2O / 1.)DMF, r.t., 30 min 2.) THF, r.t., 1 h
4: 91 percent / Et3N / CH2Cl2
5: 99 percent / H2 / 5percent Pd-BaSO4 / methanol
6: 73 percent / K2CO3 / CH2Cl2 / 0.17 h
With
ruthenium trichloride; sodium periodate; copper(l) iodide; thionyl chloride; lithium azide; sulfuric acid; water; hydrogen; potassium carbonate; triethylamine;
palladium on barium sulfate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00004a011
