1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline

Base Information

Chemical Name:1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline
CAS No.:1108621-45-9
Molecular Formula:C₂₄H₃₃NO₄
Molecular Weight:399.53
Hs Code.:

Synonyms:1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline

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Chemical Property of 1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline

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Technology Process of 1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline

There total 12 articles about 1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1108621-39-1
1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline-N-(2-methylallyloxide)

: 1108621-45-9
1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline

Guidance literature:: With acetic acid; zinc; In water; at 20 ℃; for 5h;
DOI:10.1021/jo4023149

Reference yield:

: 1108621-35-7
(Z)-2-[-2-(3-isopropoxy-4-methoxystyryl)-4-isopropoxy-5-methoxyphenyl]-N-hydroxyethanamine

: 1108621-45-9
1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / Reflux

2: water / benzene / 120 °C

3: zinc; acetic acid / water / 5 h / 20 °C

With water; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc; In tetrahydrofuran; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo4023149

Reference yield:

: 2538-98-9
4-isopropyloxy-3-methoxybenzaldehyde

: 1108621-45-9
1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline

Guidance literature:: Multi-step reaction with 9 steps

1: bromine / methanol / 2 h / 0 °C

2: trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide; triethylamine / 24 h / 20 °C

3: acetic acid / 4 h / 100 °C

4: tin(ll) chloride / ethyl acetate / 10 h / 20 °C

5: hydrogen / ethyl acetate / 5 h / 760.05 Torr

6: sodium cyanoborohydride / methanol / 1 h / 20 °C / pH Ca_. 3

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / Reflux

8: water / benzene / 120 °C

9: zinc; acetic acid / water / 5 h / 20 °C

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; water; hydrogen; bromine; sodium cyanoborohydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tin(ll) chloride; zinc; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; benzene; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/jo4023149