4-methoxy-N-(quinolin-8-yl)-2,6-bis((triisopropylsilyl)ethynyl)-benzamide

Base Information

• Chemical Name: 4-methoxy-N-(quinolin-8-yl)-2,6-bis((triisopropylsilyl)ethynyl)-benzamide
• CAS No.: 1351067-11-2
• Molecular Formula: C₃₉H₅₄N₂O₂Si₂
• Molecular Weight: 639.041
• Mol file: 1351067-11-2.mol

Synonyms:4-methoxy-N-(quinolin-8-yl)-2,6-bis((triisopropylsilyl)ethynyl)-benzamide

Chemical Property of 4-methoxy-N-(quinolin-8-yl)-2,6-bis((triisopropylsilyl)ethynyl)-benzamide

Chemical Property:

Purity/Quality:

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Technology Process of 4-methoxy-N-(quinolin-8-yl)-2,6-bis((triisopropylsilyl)ethynyl)-benzamide

There total 6 articles about 4-methoxy-N-(quinolin-8-yl)-2,6-bis((triisopropylsilyl)ethynyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methoxy-N-(8-quinolinyl)benzamide (33757-50-5) + 1-bromo-2-(triisopropylsilyl)acetylene (111409-79-1) → 4-methoxy-N-(quinolin-8-yl)-2,6-bis((triisopropylsilyl)ethynyl)-benzamide (1351067-11-2)

Guidance literature:

With cesium acetate; palladium diacetate; In toluene; at 110 ℃; for 15h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol203100u

Reference yield: 51.0%

4-methoxy-N-(8-quinolinyl)benzamide (33757-50-5) + 1-bromo-2-(triisopropylsilyl)acetylene (111409-79-1) → 4-methoxy-N-(quinolin-8-yl)-2,6-bis((triisopropylsilyl)ethynyl)-benzamide (1351067-11-2) + 4-methoxy-N-(quinolin-8-yl)-2-((triisopropylsilyl)ethynyl)-benzamide

Guidance literature:

With Bis<2-(N,N-dimethylamino)aethyl>aether; sodium carbonate; nickel dichloride; In toluene; at 100 ℃; for 24h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/acs.joc.5b00669

Reference yield: 50.0%

4-methoxy-N-(quinolin-8-yl)-2-((triisopropylsilyl)ethynyl)-benzamide + 1-bromo-2-(triisopropylsilyl)acetylene (111409-79-1) → 4-methoxy-N-(quinolin-8-yl)-2,6-bis((triisopropylsilyl)ethynyl)-benzamide (1351067-11-2)

Guidance literature:

With sodium benzoate; cobalt(III) acetylacetonate; silver carbonate; at 150 ℃; for 18h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.6b00095

upstream raw materials:

tris-iso-propylsilyl acetylene

4-methoxy-N-(8-quinolinyl)benzamide

1-bromo-2-(triisopropylsilyl)acetylene

4-methoxy-benzoyl chloride