33757-50-5Relevant articles and documents
Copper-Mediated Remote Highly Site-Selective C–H Bond Bromination and Chlorination of Quinolines at the C5 Position that is Geometrically Difficult to Access
Rao, Naidu Sambasiva,Reddy, Ganapam Manohar,Sridhar,Sarma, Maheswaran Harihara
, p. 438 - 442 (2017)
A concise, simple, and efficient method for remote C–H bond halogenation (Br and Cl) of 8-aminoquinoline scaffolds at the geometrically difficult-to-access C5 position was explored with diverse substrate combinations in DMF. This protocol made use of inex
Transition Metal-Free Regioselective Remote C?H Bond 2,2,2-Trifluoroethoxylation of 8-Aminoquinoline Derivatives at the C5 Position
Ruyet, Louise,Poisson, Thomas,Besset, Tatiana
supporting information, p. 3407 - 3410 (2021/06/28)
The regioselective 2,2,2-trifluoroethoxylation at the C5 position of amides derived from the 8-aminoquinoline has been developed. In the presence of PIDA, an unprecedented and undirected transition metal-free transformation was achieved using the readily available and appealing 2,2,2-trifluoroethanol as the fluorinated source. The selective distal 2,2,2-trifluoroethoxylation of an array of amides was achieved in moderate to good yields (12 examples, up to 61 % yield). This approach provided efficient access to high-value added fluorinated quinoline derivatives, key building blocks for bulk and fine chemical industry.
C-H Amidation and Amination of Arenes and Heteroarenes with Amide and Amine using Cu-MnO as a Reusable Catalyst under Mild Conditions
Singh, Harshvardhan,Sen, Chiranjit,Suresh, Eringathodi,Panda, Asit B.,Ghosh, Subhash C.
, p. 3261 - 3275 (2021/02/16)
An atom-economical and efficient route for the direct amidation and amination of aryl C-H bonds using our synthesized recyclable heterogeneous Cu-MnO catalyst is reported here. The direct C-H amidation was carried out using a simple amide without any prea
