7-((4-(trifluoromethyl)benzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one

Base Information

Chemical Name:7-((4-(trifluoromethyl)benzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one
CAS No.:1616248-11-3
Molecular Formula:C₂₆H₂₁F₃O₆
Molecular Weight:486.444
Hs Code.:

Synonyms:7-((4-(trifluoromethyl)benzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-((4-(trifluoromethyl)benzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one

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Technology Process of 7-((4-(trifluoromethyl)benzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one

There total 11 articles about 7-((4-(trifluoromethyl)benzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.2%

: 29096-94-4
7-hydroxy-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one

: 1616248-11-3
7-((4-(trifluoromethyl)benzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃;
DOI:10.1016/j.bmcl.2014.04.121

Reference yield:

: 1013634-99-5
7-hydroxy-3-iodo-4H-chromen-4-one

: 1616248-11-3
7-((4-(trifluoromethyl)benzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 3-Methylpyridine / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux

2: sodium carbonate; palladium on activated charcoal / 1,2-dimethoxyethane; water / 1 h / 45 °C

3: toluene-4-sulfonic acid / methanol; tetrahydrofuran / 1 h / 60 °C

4: potassium carbonate / acetone / 20 °C

With 3-Methylpyridine; palladium on activated charcoal; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 5,5-dimethyl-1,3-cyclohexadiene; water; acetone; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2014.04.121

Reference yield:

: 1422513-84-5
3-iodo-8,8-dimethylpyrano[2,3-f]chromen-4(8H)-one

: 1616248-11-3
7-((4-(trifluoromethyl)benzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; palladium on activated charcoal / 1,2-dimethoxyethane; water / 1 h / 45 °C

2: toluene-4-sulfonic acid / methanol; tetrahydrofuran / 1 h / 60 °C

3: potassium carbonate / acetone / 20 °C

With palladium on activated charcoal; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetone; 1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2014.04.121