1013634-99-5

Basic information

• Product Name: 7-hydroxy-3-iodo-4H-chromen-4-one
• Synonyms: 7-hydroxy-3-iodo-4H-chromen-4-one;7-HYDROXY-3-IODO-4H-CHROMEN-4-ONE(WXC06255)
• CAS NO: 1013634-99-5
• Molecular Formula: C₉H₅IO₃
• Molecular Weight: 288.03867
• Mol File: 1013634-99-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 381.0±42.0 °C(Predicted)
• Appearance: /
• Density: 2.15±0.1 g/cm3(Predicted)
• PKA: 6.53±0.20(Predicted)
• CAS DataBase Reference: 7-hydroxy-3-iodo-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-3-iodo-4H-chromen-4-one(1013634-99-5)
• EPA Substance Registry System: 7-hydroxy-3-iodo-4H-chromen-4-one(1013634-99-5)

Safety Data

• Hazardous Substances Data: 1013634-99-5(Hazardous Substances Data)

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 73220-33-4 (2E)-3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl)-2-propen-1-one 
• 935659-63-5 3-iodo-7-((tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one 
• 1124174-55-5 C₁₆H₂₁NO₄ 
• 111841-07-7 2-hydroxy-4-(tetrahydropyran-2-yloxy)acetophenone 
• 1388223-86-6 C₁₅H₁₉NO₃ 
• 5751-52-0 7-methoxy-4H-chromen-4-one 
• 94719-82-1 C₁₀H₁₀O₄ 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 73220-42-5 3-iodo-7-methoxy-chromen-4-one 

Downstream Products

• 1013635-00-1 3-iodo-7-({4-methyl-2-[4-(trifluoromethyl)phenyl](1,3-thiazol-5-yl)}methoxy)chromen-4-one 
• 1616248-07-7 7-((3-chlorobenzyl)oxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one 
• 485-72-3 7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on 

Relevant articles and documents

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Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents

A series of barbigerone analogues (7a-7w, 13a-13x) were designed, synthesized and biologically evaluated for their anti-proliferative and anti-angiogenic activities. Among these compounds, compound 13a exhibited the most potent inhibitory effect on the proliferation of HUVECs, HepG2, A375, U251, B16, and HCT116 cells (IC50 = 3.80, 0.28, 1.58, 3.50, 1.09 and 0.68 μM, respectively). Compound 13a inhibited the angiogenesis in zebrafish embryo assay in a concentration-dependent manner. Furthermore, 13a also effectively inhibited the migration and capillary like tube formation of human umbilical vein endothelial cell in vitro. These results support the further investigation of this class of compounds as potential anti-proliferative and anti-angiogenesis agents.