ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate

Base Information

• Chemical Name: ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate
• CAS No.: 1335027-53-6
• Molecular Formula: C₁₆H₁₈ClFO₃
• Molecular Weight: 312.769

Synonyms:ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate

Chemical Property of ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate

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Technology Process of ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate

There total 2 articles about ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.3%

3-chloro-4-fluorobenzyl bromide (192702-01-5) + ethyl 3-cyclobutyl-3-oxopropanoate (24922-01-8) → ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate (1335027-53-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; at 80 ℃; for 18h;

Reference yield:

→ ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate (1335027-53-6)

Guidance literature:

Reference yield: 23.74%

3(5)-amino-1,2,4-triazole (61-82-5) + ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate (1335027-53-6) → 6-[(3-chloro-4-fluoro-phenyl)methyl]-5-cyclobutyl-4H-[1,2,4]triazolo[5,1-b]pyrimidin-7-one (1335026-56-6)

Guidance literature:

With toluene-4-sulfonic acid; at 160 ℃; for 18h; Neat (no solvent);

upstream raw materials:

3-chloro-4-fluorobenzyl bromide

ethyl 3-cyclobutyl-3-oxopropanoate

Downstream raw materials:

6-[(3-chloro-4-fluoro-phenyl)methyl]-5-cyclobutyl-4H-[1,2,4]triazolo[5,1-b]pyrimidin-7-one

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