(3S,4S,6S)-5,5-dideutero-4-(dimethyl(phenyl)silyl)-3-ethoxycarbonyl-6-undecyltetrahydro-2H-pyran-2-one

Base Information

Chemical Name:(3S,4S,6S)-5,5-dideutero-4-(dimethyl(phenyl)silyl)-3-ethoxycarbonyl-6-undecyltetrahydro-2H-pyran-2-one
CAS No.:1535171-17-5
Molecular Formula:C₂₇H₄₄O₄Si
Molecular Weight:462.714
Hs Code.:

Synonyms:(3S,4S,6S)-5,5-dideutero-4-(dimethyl(phenyl)silyl)-3-ethoxycarbonyl-6-undecyltetrahydro-2H-pyran-2-one

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Chemical Property of (3S,4S,6S)-5,5-dideutero-4-(dimethyl(phenyl)silyl)-3-ethoxycarbonyl-6-undecyltetrahydro-2H-pyran-2-one

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Technology Process of (3S,4S,6S)-5,5-dideutero-4-(dimethyl(phenyl)silyl)-3-ethoxycarbonyl-6-undecyltetrahydro-2H-pyran-2-one

There total 5 articles about (3S,4S,6S)-5,5-dideutero-4-(dimethyl(phenyl)silyl)-3-ethoxycarbonyl-6-undecyltetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1535171-16-4
ethyl (3S)-3-(dimethylphenylsilyl)-4,4-dideutero-2-ethoxycarbonyl-5-oxohexadecanoate

: 1535171-17-5
(3S,4S,6S)-5,5-dideutero-4-(dimethyl(phenyl)silyl)-3-ethoxycarbonyl-6-undecyltetrahydro-2H-pyran-2-one

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃; for 5h;
DOI:10.1002/jlcr.3081

Reference yield:

: 1535171-09-5
1,1,1-trideuteriotridecan-2-one

: 1535171-17-5
(3S,4S,6S)-5,5-dideutero-4-(dimethyl(phenyl)silyl)-3-ethoxycarbonyl-6-undecyltetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; trifluoroacetic acid; water-d2 / 1-methyl-pyrrolidin-2-one / -10 °C

2: sodium tetrahydroborate / ethanol / 5 h / 0 °C

With sodium tetrahydroborate; (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; water-d2; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; ethanol; 1: |Michael Addition;
DOI:10.1002/jlcr.3081

Reference yield:

: 943346-53-0
N-methoxy-N-methyl dodecanamide

: 1535171-17-5
(3S,4S,6S)-5,5-dideutero-4-(dimethyl(phenyl)silyl)-3-ethoxycarbonyl-6-undecyltetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 1.5 h / 0 °C

2: (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; trifluoroacetic acid; water-d2 / 1-methyl-pyrrolidin-2-one / -10 °C

3: sodium tetrahydroborate / ethanol / 5 h / 0 °C

With sodium tetrahydroborate; (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; water-d2; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; 2: |Michael Addition;
DOI:10.1002/jlcr.3081