ethyl (3S)-3-(dimethylphenylsilyl)-4,4-dideutero-2-ethoxycarbonyl-5-oxohexadecanoate

Base Information

Chemical Name:ethyl (3S)-3-(dimethylphenylsilyl)-4,4-dideutero-2-ethoxycarbonyl-5-oxohexadecanoate
CAS No.:1535171-16-4
Molecular Formula:C₂₉H₄₈O₅Si
Molecular Weight:506.767
Hs Code.:

Synonyms:ethyl (3S)-3-(dimethylphenylsilyl)-4,4-dideutero-2-ethoxycarbonyl-5-oxohexadecanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (3S)-3-(dimethylphenylsilyl)-4,4-dideutero-2-ethoxycarbonyl-5-oxohexadecanoate

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Technology Process of ethyl (3S)-3-(dimethylphenylsilyl)-4,4-dideutero-2-ethoxycarbonyl-5-oxohexadecanoate

There total 2 articles about ethyl (3S)-3-(dimethylphenylsilyl)-4,4-dideutero-2-ethoxycarbonyl-5-oxohexadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1535171-09-5
1,1,1-trideuteriotridecan-2-one

: 130247-53-9
ethyl 2-ethoxycarbonyl-3-dimethyl(phenyl)silyl-2-propenoate

: 1535171-16-4
ethyl (3S)-3-(dimethylphenylsilyl)-4,4-dideutero-2-ethoxycarbonyl-5-oxohexadecanoate

Guidance literature:: With (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; water-d2; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; at -10 ℃;
DOI:10.1002/jlcr.3081

Reference yield:

: 112-16-3
n-dodecanoyl chloride

: 1535171-16-4
ethyl (3S)-3-(dimethylphenylsilyl)-4,4-dideutero-2-ethoxycarbonyl-5-oxohexadecanoate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 1 h / 20 °C

2: diethyl ether / 1.5 h / 0 °C

3: (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; trifluoroacetic acid; water-d2 / 1-methyl-pyrrolidin-2-one / -10 °C

With pyridine; (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; water-d2; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane; 3: |Michael Addition;
DOI:10.1002/jlcr.3081