3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE

Base Information

• Chemical Name: 3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE
• CAS No.: 387350-39-2
• Molecular Formula: C7H7F3N2
• Molecular Weight: 176.141
• Hs Code.: 2933399090
• European Community (EC) Number: 671-088-1
• DSSTox Substance ID: DTXSID10372225
• Wikidata: Q72439800
• Mol file: 387350-39-2.mol

Synonyms:((6-(Trifluoromethyl)pyridin-3-yl)methyl)amine;3-Aminomethyl-6-(trifluoromethyl)pyridine;5-(Aminomethyl)-2-(trifluoromethyl)pyridine;[6-(Trifluoromethyl)pyridin-3-yl]methanamine;1-[6-(Trifluoromethyl)pyridin-3-yl]methanamine;

Chemical Property of 3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE

Chemical Property:

• Vapor Pressure: 0.227mmHg at 25°C
• Refractive Index: 1.466
• Boiling Point: 207.333 °C at 760 mmHg
• PKA: 7.85±0.29(Predicted)
• Flash Point: 79.193 °C
• PSA: 38.91000
• Density: 1.294 g/cm³
• LogP: 2.25940
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 176.05613272
• Heavy Atom Count: 12
• Complexity: 146

Purity/Quality:

99% ^*data from raw suppliers

3-(Aminomethyl)-6-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 28-37/38-41-43
• Safety Statements: 26-28-36/37-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1CN)C(F)(F)F

Technology Process of 3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE

There total 1 articles about 3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(azidomethyl)-2-(trifluoromethyl)pyridine (1108556-21-3) → 1-(6-(trifluoromethyl)pyridin-3-yl)methanamine (387350-39-2)

Guidance literature:

5-(azidomethyl)-2-(trifluoromethyl)pyridine; With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; for 1.25h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 100.0%

4-Nitrophenyl chloroformate (7693-46-1) + 1-(6-(trifluoromethyl)pyridin-3-yl)methanamine (387350-39-2) → 4-nitrophenyl ((6-(trifluoromethyl)pyridin-3-yl)methyl)carbamate

Guidance literature:

With pyridine; In dichloromethane; at -30 - 0 ℃; for 8h;

Reference yield: 86.0%

6-benzyl-4-chloro-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidine (914612-23-0) + 1-(6-(trifluoromethyl)pyridin-3-yl)methanamine (387350-39-2) → 6-benzyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (1073428-54-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 200 ℃; for 3.5h; Microwave irradiation;

upstream raw materials:

5-(azidomethyl)-2-(trifluoromethyl)pyridine

Downstream raw materials:

6-benzyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

5-(3-hydroxyazetidine-1-carbonyl)-4'-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)biphenyl-3-carboxamide

C₂₆H₂₁ClF₃N₃O₃

((R)-2-(2-fluoro-phenyl)-1-{[(6-trifluoromethyl-pyridin-3-ylmethyl)-sulphamoyl]-methyl}-ethyl)-carbamic acid benzyl ester

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