methyl 4-(1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate

Base Information

Chemical Name:methyl 4-(1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate
CAS No.:1616364-24-9
Molecular Formula:C₂₃H₂₄ClN₃O₄
Molecular Weight:441.914
Hs Code.:

Synonyms:methyl 4-(1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate

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Chemical Property of methyl 4-(1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate

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Technology Process of methyl 4-(1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate

There total 1 articles about methyl 4-(1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1616364-23-8
4-(3-carboxy-1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)propyl)-3-methylbenzoic acid

: 74-88-4
methyl iodide

: 1616364-24-9
methyl 4-(1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield: 50.0%

: 1616364-24-9
methyl 4-(1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate

: 6148-64-7
ethyl potassium malonate

: 1616364-25-0
methyl 4-(1-(5-(2-ethoxy-2-oxoethyl)-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate

Guidance literature:: With dmap; bis(η3-allyl-μ-chloropalladium(II)); XPhos; In 1,3,5-trimethyl-benzene; at 120 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1616364-24-9
methyl 4-(1-(5-chloro-1-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-4-methoxy-4-oxobutyl)-3-methylbenzoate

: 1616364-27-2
methyl 3-methyl-4-(1-methyl-7-oxo-3-(pyridin-2-yl)-1,4,5,6,7,8-hexahydrocyclohepta[c]pyrazol-4-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: XPhos; dmap; bis(η3-allyl-μ-chloropalladium(II)) / 1,3,5-trimethyl-benzene / 16 h / 120 °C / Inert atmosphere

2.1: toluene / 16 h / Molecular sieve; Reflux

2.2: 22 h / 0 - 20 °C

3.1: potassium hydroxide / diethyl ether; tetrahydrofuran; water / 0 °C / Inert atmosphere

With dmap; bis(η3-allyl-μ-chloropalladium(II)); potassium hydroxide; XPhos; In tetrahydrofuran; diethyl ether; water; toluene; 1,3,5-trimethyl-benzene;