3-(8-methyl-8-azabicyclo-[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile hydrochloride

Base Information

Chemical Name:3-(8-methyl-8-azabicyclo-[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile hydrochloride
CAS No.:1428580-74-8
Molecular Formula:C₂₃H₂₆N₂*ClH
Molecular Weight:366.934
Hs Code.:

Synonyms:3-(8-methyl-8-azabicyclo-[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile hydrochloride

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Chemical Property of 3-(8-methyl-8-azabicyclo-[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile hydrochloride

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Technology Process of 3-(8-methyl-8-azabicyclo-[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile hydrochloride

There total 4 articles about 3-(8-methyl-8-azabicyclo-[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 7677-24-9
trimethylsilyl cyanide

: 95131-86-5
2-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-1,1-diphenylethanol

: 1428580-74-8
3-(8-methyl-8-azabicyclo-[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile hydrochloride

Guidance literature:: trimethylsilyl cyanide; 2-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-1,1-diphenylethanol; With tin(IV) chloride; In dichloromethane; at -5 - 25 ℃; Inert atmosphere;

With hydrogenchloride; In isopropyl alcohol; at 20 - 80 ℃; for 4.75h; Concentration; Inert atmosphere;
DOI:10.1021/op3002933

Reference yield:

: 591-51-5
phenyllithium

: 1428580-74-8
3-(8-methyl-8-azabicyclo-[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: dibutyl ether / 0 °C / Inert atmosphere

2.1: tin(IV) chloride / dichloromethane / -5 - 25 °C / Inert atmosphere

2.2: 4.75 h / 20 - 80 °C / Inert atmosphere

With tin(IV) chloride; In dichloromethane; dibutyl ether;
DOI:10.1021/op3002933

Reference yield:

: 924646-52-6
methyl (3-endo)-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)acetate

: 1428580-74-8
3-(8-methyl-8-azabicyclo-[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: dibutyl ether / 5 - 20 °C / Inert atmosphere; Large scale

2.1: tin(IV) chloride / dichloromethane / -5 - 25 °C / Inert atmosphere

2.2: 4.75 h / 20 - 80 °C / Inert atmosphere

With tin(IV) chloride; In dichloromethane; dibutyl ether;
DOI:10.1021/op3002933