3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine

Base Information

Chemical Name:3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine
CAS No.:1246355-26-9
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

Synonyms:3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine

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Technology Process of 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine

There total 1 articles about 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 191162-30-8
(S)-2-((5-bromopyridin-3-yloxy)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 62-53-3
aniline

: 1246355-26-9
3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 98 - 100 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm100765u

Reference yield: 100.0%

: 1246355-26-9
3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine

: 3-[(2(S)-pyrrolidinyl)methoxy]-5-phenylaminopyridine trihydrochloride

Guidance literature:: 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine; With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; Inert atmosphere;

With trifluoroacetic acid; In water; Further stages;
DOI:10.1021/jm100765u

Reference yield:

: 1246355-26-9
3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine

: 76-05-1
trifluoroacetic acid

: C₂HF₃O₂*C₁₆H₁₉N₃O

Guidance literature:: 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-phenylaminopyridine; With hydrogenchloride; methanol; In diethyl ether; at 20 ℃; Inert atmosphere;

trifluoroacetic acid; In water;
DOI:10.1021/jm100765u