N-(2-amino-5-(thiophen-2-yl)phenyl)-3-azido-4-(2-azidoethoxy)benzamide

Base Information

Chemical Name:N-(2-amino-5-(thiophen-2-yl)phenyl)-3-azido-4-(2-azidoethoxy)benzamide
CAS No.:1393745-24-8
Molecular Formula:C₁₉H₁₆N₈O₂S
Molecular Weight:420.454
Hs Code.:

Synonyms:N-(2-amino-5-(thiophen-2-yl)phenyl)-3-azido-4-(2-azidoethoxy)benzamide

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Chemical Property of N-(2-amino-5-(thiophen-2-yl)phenyl)-3-azido-4-(2-azidoethoxy)benzamide

Chemical Property:

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Technology Process of N-(2-amino-5-(thiophen-2-yl)phenyl)-3-azido-4-(2-azidoethoxy)benzamide

There total 6 articles about N-(2-amino-5-(thiophen-2-yl)phenyl)-3-azido-4-(2-azidoethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₄N₈O₄S

: 1393745-24-8
N-(2-amino-5-(thiophen-2-yl)phenyl)-3-azido-4-(2-azidoethoxy)benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.06.017

Reference yield:

: 1393745-16-8
3-azido-4-hydroxybenzoate

: 1393745-24-8
N-(2-amino-5-(thiophen-2-yl)phenyl)-3-azido-4-(2-azidoethoxy)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 8 h / 0 - 20 °C

2.1: potassium carbonate / acetone / 5 h / Reflux

3.1: potassium hydroxide / tetrahydrofuran; water / 10 h / 70 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 78 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With thionyl chloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.06.017

Reference yield:

: 1393745-18-0
C₁₀H₁₀N₆O₃

: 1393745-24-8
N-(2-amino-5-(thiophen-2-yl)phenyl)-3-azido-4-(2-azidoethoxy)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / tetrahydrofuran; water / 10 h / 70 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 78 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.06.017