3-(4-methoxyphenyl)-N-{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}-3-{{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}amino}propanamide

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-N-{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}-3-{{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}amino}propanamide
• CAS No.: 544697-01-0
• Molecular Formula: C₂₈H₃₆N₄O₆S₂
• Molecular Weight: 588.749
• Mol file: 544697-01-0.mol

Synonyms:3-(4-methoxyphenyl)-N-{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}-3-{{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}amino}propanamide

Chemical Property of 3-(4-methoxyphenyl)-N-{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}-3-{{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}amino}propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxyphenyl)-N-{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}-3-{{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}amino}propanamide

There total 3 articles about 3-(4-methoxyphenyl)-N-{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}-3-{{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}amino}propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.5%

p-toluenesulfonyl chloride (98-59-9) + N-(2-aminoethyl)-3-[(2-aminoethyl)amino]-3-(4-methoxyphenyl)propanamide (544696-99-3) → 3-(4-methoxyphenyl)-N-{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}-3-{{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}amino}propanamide (544697-01-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1002/hlca.200390033

Reference yield:

(E)-3-(4-methoxyphenyl)acrylic acid (943-89-5) → 3-(4-methoxyphenyl)-N-{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}-3-{{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}amino}propanamide (544697-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / HCl(g) / 4 h / Heating

2: 100 percent / 24 h / 70 °C

3: 67.5 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; triethylamine; In dichloromethane; 2: Richman-Atkins procedure;

DOI:10.1002/hlca.200390033

Reference yield:

3-(4-methoxy-phenyl)acrylic acid methyl ester (3901-07-3) → 3-(4-methoxyphenyl)-N-{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}-3-{{2-{[(4-methylphenyl)sulfonyl]amino}ethyl}amino}propanamide (544697-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 24 h / 70 °C

2: 67.5 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

With triethylamine; In dichloromethane; 1: Richman-Atkins procedure;

DOI:10.1002/hlca.200390033

upstream raw materials:

p-toluenesulfonyl chloride

N-(2-aminoethyl)-3-[(2-aminoethyl)amino]-3-(4-methoxyphenyl)propanamide

(E)-3-(4-methoxyphenyl)acrylic acid

3-(4-methoxy-phenyl)acrylic acid methyl ester

Downstream raw materials:

7-(4-methoxyphenyl)-1,11-bis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacycloheptadecan-5-one