N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester

Base Information

Chemical Name:N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester
CAS No.:1026189-22-9
Molecular Formula:C₃₁H₃₈N₄O₇
Molecular Weight:578.665
Hs Code.:

N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester

Synonyms:N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester

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Chemical Property of N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester

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Technology Process of N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester

There total 6 articles about N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95501-78-3
N-Benzyloxycarbonyl-L-valyl-L-prolyl-L-valinal

: 1026189-22-9
N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: water / tetrahydrofuran / 4.5 h / Ambient temperature

2: acetyl chloride / CHCl₃ / 16 h / Ambient temperature

3: 35 percent / ethanol / 4 h / 60 °C

4: 96 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 2585.7 Torr

5: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole monohydrate / tetrahydrofuran / 16 h / Ambient temperature

With water; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm00020a011

Reference yield:

: 95-55-6
2-amino-phenol

: 1026189-22-9
N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / ethanol / 4 h / 60 °C

2: 96 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 2585.7 Torr

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole monohydrate / tetrahydrofuran / 16 h / Ambient temperature

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00020a011

Reference yield:

: <(benzyloxycarbonyl)-L-valyl>-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

: 1026189-22-9
N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-terephthalamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: acetyl chloride / CHCl₃ / 16 h / Ambient temperature

2: 35 percent / ethanol / 4 h / 60 °C

3: 96 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 2585.7 Torr

4: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole monohydrate / tetrahydrofuran / 16 h / Ambient temperature

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm00020a011