2-benzyl-1-chloro-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile

Base Information

• Chemical Name: 2-benzyl-1-chloro-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile
• CAS No.: 121105-86-0
• Molecular Formula: C₂₀H₁₄ClN₃
• Molecular Weight: 331.804
• Mol file: 121105-86-0.mol

Synonyms:2-benzyl-1-chloro-3-methylpyrido<1,2-a>benzimidazole-4-carbonitrile

Chemical Property of 2-benzyl-1-chloro-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile

Chemical Property:

• Melting Point: 220-223 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
• PKA: 2.18±0.50(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-BENZYL-1-CHLORO-3-METHYLBENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-benzyl-1-chloro-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile

There total 7 articles about 2-benzyl-1-chloro-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-benzyl-3-methyl-1-oxo-1H,5H-pyrido<1,2-a>benzimidazole-4-carbonitrile (121105-74-6) → 2-benzyl-1-chloro-3-methylpyrido<1,2-a>benzimidazole-4-carbonitrile (121105-86-0)

Guidance literature:

With trichlorophosphate; for 1h; Heating;

DOI:10.1002/jhet.5570250622

Reference yield:

benzyl bromide (100-39-0) → 2-benzyl-1-chloro-3-methylpyrido<1,2-a>benzimidazole-4-carbonitrile (121105-86-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 70 °C

2: ammonium acetate / 1 h / 150 °C

3: trichlorophosphate / 2 h / 130 °C

With potassium tert-butylate; ammonium acetate; trichlorophosphate; In tetrahydrofuran; tert-butyl alcohol;

DOI:10.1021/acsinfecdis.6b00205

Reference yield:

C20H15N3O → 2-benzyl-1-chloro-3-methylpyrido<1,2-a>benzimidazole-4-carbonitrile (121105-86-0)

Guidance literature:

With trichlorophosphate; at 130 ℃; for 2h;

DOI:10.1021/acsinfecdis.6b00205

upstream raw materials:

2-benzyl-3-methyl-1-oxo-1H,5H-pyrido<1,2-a>benzimidazole-4-carbonitrile

1H-benzimidazol-2-acetonitrile

Ethyl 2-benzylacetoacetate

benzyl bromide

Downstream raw materials:

2-benzyl-1-(cyclohexylamino)-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile

2-benzyl-3-methyl-1-(p-tolylamino)benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile

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