17α-{[4-(ω-(p-formylphenyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol

Base Information

Chemical Name:17α-{[4-(ω-(p-formylphenyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol
CAS No.:918803-12-0
Molecular Formula:C₄₅H₅₆O₁₀
Molecular Weight:756.934
Hs Code.:

Synonyms:17α-{[4-(ω-(p-formylphenyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol

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Chemical Property of 17α-{[4-(ω-(p-formylphenyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol

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Technology Process of 17α-{[4-(ω-(p-formylphenyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol

There total 2 articles about 17α-{[4-(ω-(p-formylphenyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 944544-97-2
17α-{[4-(ω-(p-methansulfonyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol

: 918803-12-0
17α-{[4-(ω-(p-formylphenyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/anie.200601923

Reference yield:

: 4-(2-{2-[2-(2-{2-[2-(4-iodo-phenoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzaldehyde

: 57-63-6
ethinyl estradiol

: 918803-12-0
17α-{[4-(ω-(p-formylphenyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triethylamine; tris-(o-tolyl)phosphine; copper(l) iodide; at 20 ℃;
DOI:10.1002/anie.200601923

Reference yield:

: 918803-12-0
17α-{[4-(ω-(p-formylphenyl)-hexa(ethylenglycol)yl)phenyl]ethynyl}estra-1,3,5(10)-triene-3,17β-diol

: N-(2-{4-[2-(2-{2-[2-(2-{2-[4-(3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ylethynyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-benzylamino}-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 20 °C

2: 55 mg / NaBH₄; methanol / 20 °C

With methanol; sodium tetrahydroborate; In methanol;
DOI:10.1002/anie.200601923