(4-chloro-pyridin-3-yl)-(2-trifluoromethyl-phenyl)-methanol

Base Information

• Chemical Name: (4-chloro-pyridin-3-yl)-(2-trifluoromethyl-phenyl)-methanol
• CAS No.: 156095-82-8
• Molecular Formula: C₁₃H₉ClF₃NO
• Molecular Weight: 287.669
• Mol file: 156095-82-8.mol

Synonyms:(4-chloro-pyridin-3-yl)-(2-trifluoromethyl-phenyl)-methanol

Chemical Property of (4-chloro-pyridin-3-yl)-(2-trifluoromethyl-phenyl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-chloro-pyridin-3-yl)-(2-trifluoromethyl-phenyl)-methanol

There total 1 articles about (4-chloro-pyridin-3-yl)-(2-trifluoromethyl-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chloropyridine (626-61-9) + 2-Trifluoromethylbenzaldehyde (447-61-0) → (4-chloro-pyridin-3-yl)-(2-trifluoromethyl-phenyl)-methanol (156095-82-8)

Guidance literature:

4-Chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 1.5h;

2-Trifluoromethylbenzaldehyde; In tetrahydrofuran; at -70 ℃; for 1.5h;

DOI:10.1128/AAC.48.1.313-318.2004

Reference yield:

benzyl bromide (100-39-0) + (4-chloro-pyridin-3-yl)-(2-trifluoromethyl-phenyl)-methanol (156095-82-8) → 3-[benzyloxy-(2-trifluoromethyl-phenyl)-methyl]-4-chloro-pyridine (156096-33-2)

Guidance literature:

With sodium hydride; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

DOI:10.1128/AAC.48.1.313-318.2004

Reference yield:

(4-chloro-pyridin-3-yl)-(2-trifluoromethyl-phenyl)-methanol (156095-82-8) → 4-azido-3-[benzyloxy-(2-trifluoromethyl-phenyl)-methyl]-pyridine

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / nBu₄NI / dimethylformamide / 2 h / 0 °C

2: 70 percent / sodium azide / 18-crown-6 / dimethylformamide; H₂O / 18 h / 95 °C

With sodium azide; sodium hydride; 18-crown-6 ether; tetra-(n-butyl)ammonium iodide; In water; N,N-dimethyl-formamide;

DOI:10.1128/AAC.48.1.313-318.2004

upstream raw materials:

4-Chloropyridine

2-Trifluoromethylbenzaldehyde

Downstream raw materials:

3-[benzyloxy-(2-trifluoromethyl-phenyl)-methyl]-4-chloro-pyridine