(7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

Base Information

Chemical Name:(7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine
CAS No.:261944-24-5
Molecular Formula:C₁₉H₂₁N₃O₂
Molecular Weight:323.395
Hs Code.:

Synonyms:(7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

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Chemical Property of (7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

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Technology Process of (7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

There total 5 articles about (7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214194-01-1
(7R,8R,9R)-2,3-dimethyl-7,8-dihydroxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

: 74-88-4
methyl iodide

: 261944-24-5
(7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

Guidance literature:: (7R,8R,9R)-2,3-dimethyl-7,8-dihydroxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine; With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; paraffin oil; for 1h; Reagent/catalyst; Solvent;

Reference yield:

: 214194-14-6
N-(2,3-dimethylimidazo[1,2-a]pyridin-8-yl)-2,2-dimethylpropanamide

: 261944-24-5
(7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -75 - -65 °C / Inert atmosphere

1.2: 0.58 h / -65 - -30 °C

2.1: sulfuric acid / water / 50.57 h / 20 °C / Cooling with ice

3.1: methanol; sodium tetrahydroborate / 0.67 h / -5 - 0 °C

4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 1 h / 20 °C

4.2: 1 h

With methanol; sodium tetrahydroborate; sulfuric acid; tert.-butyl lithium; sodium hydride; In diethyl ether; water; N,N-dimethyl-formamide; paraffin oil; pentane;

Reference yield:

: 214194-00-0
(8R,9R)-2,3-Dimethyl-8-hydroxy-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridin-7-one

: 261944-24-5
(7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; sodium tetrahydroborate / 0.67 h / -5 - 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 1 h / 20 °C

2.2: 1 h

With methanol; sodium tetrahydroborate; sodium hydride; In N,N-dimethyl-formamide; paraffin oil;