methyl n-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl} isonipecotate

Base Information

Chemical Name:methyl n-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl} isonipecotate
CAS No.:1357390-53-4
Molecular Formula:C₂₄H₃₁N₃O₅S
Molecular Weight:473.593
Hs Code.:

Synonyms:methyl n-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl} isonipecotate

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Chemical Property of methyl n-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl} isonipecotate

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Technology Process of methyl n-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl} isonipecotate

There total 4 articles about methyl n-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl} isonipecotate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2971-79-1
isonipecotic acid methyl ester

: 1341127-10-3
2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl methanesulfonate

: 1357390-53-4
methyl n-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl} isonipecotate

Guidance literature:: With potassium carbonate; In acetonitrile; for 20h; Reflux;
DOI:10.1016/j.ejmech.2011.10.019

Reference yield:

: 1341126-59-7
2-(3-phenoxybenzyl)-1,2,5-thiadiazolidine 1,1-dioxide

: 1357390-53-4
methyl n-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl} isonipecotate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; acetonitrile; mineral oil / 0.25 h

1.2: 20 °C

2.1: lithium borohydride / tetrahydrofuran; ethanol / 20 °C

3.1: triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

4.1: potassium carbonate / acetonitrile / 20 h / Reflux

With lithium borohydride; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.ejmech.2011.10.019

Reference yield:

: 1341126-95-1
methyl [5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetate

: 1357390-53-4
methyl n-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl} isonipecotate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran; ethanol / 20 °C

2: triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

3: potassium carbonate / acetonitrile / 20 h / Reflux

With lithium borohydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.ejmech.2011.10.019