dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate

Base Information

Chemical Name:dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate
CAS No.:812667-21-3
Molecular Formula:C₃₃H₃₁F₂N₂O₅P
Molecular Weight:604.59
Hs Code.:

Synonyms:dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate

Suppliers and Price of dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate

There total 6 articles about dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 639078-59-4
(2S)-4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-N,N-dimethyl-2,5-dihydro-1H-pyrrole-1-carboxamide

: 17176-77-1
Dibenzyl phosphite

: 812667-21-3
dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate

Guidance literature:: With tetrachloromethane; dmap; N,N-diethyl-N-isopropylamine; In acetonitrile; at 0 - 25 ℃;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 635724-41-3
tert-butyl 3-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

: 812667-21-3
dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Pd(OAc)2; Ph₃As / 0.5 h / 150 °C / microwave irradiation

2.1: 95 percent / TFA / CH₂Cl₂

3.1: 70 °C

3.2: MeI / 60 °C

4.1: 90 percent / K₂CO₃ / dimethylformamide

5.1: 79 percent / i-PrNEt₂; DMAP; CCl₄ / acetonitrile / 0 - 25 °C

With tetrachloromethane; dmap; palladium diacetate; N,N-diethyl-N-isopropylamine; triphenyl-arsane; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Heck coupling;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 884651-22-3
2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

: 812667-21-3
dibenzyl 3-{(2S)-4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-1H-pyrrol-2-yl)phenyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 70 °C

1.2: MeI / 60 °C

2.1: 90 percent / K₂CO₃ / dimethylformamide

3.1: 79 percent / i-PrNEt₂; DMAP; CCl₄ / acetonitrile / 0 - 25 °C

With tetrachloromethane; dmap; N,N-diethyl-N-isopropylamine; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.12.094